The irf family of transcription factors

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August undefined, 2024

WebTranscription factors of the interferon regulatory factor (IRF) family have been identified as critical mediators of early inflammatory gene transcription in infected cells. We recently determined that, besides IRF-3 and IRF-7, IRF-5 serves as a direct transducer of virus-mediated signaling. WebInterferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-helix DNA-binding motif. Following the initial …

Frontiers Therapeutic Targeting of IRFs: Pathway-Dependence or ...

Web2 hours ago · The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Drosophila only encodes one member of the family, Bonus. Bonus has been implicated in embryonic … WebImmune cell development. IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, … night shift work and cancer

Frontiers Therapeutic Targeting of IRFs: Pathway …

WebSep 29, 2024 · The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses. WebIRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and … WebNov 20, 2024 · Interferon Regulatory Factors (IRFs) are a family of transcription factors that signal downstream of multiple pathways, including Toll-like receptor (TLR), retinoic acid-inducible gene I (RIG-I), melanoma differentiation associated gene 5 (MDA5), and B cell receptor (BCR) signaling pathways to regulate gene expression involved in both innate … n scale cn covered hopper

Cooperative Transcription Factor Complexes in Control Science

Expression and function of chemokines during viral infections: …

Web2 hours ago · The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by … WebThe IRF family of transcription factors is involved in many aspects of the immune response . For instance, IRF‐1‐deficient mice fail to develop NK cells and are hyporesponsive to IFN‐γ. For instance, IRF‐1‐deficient mice fail to develop NK cells and are hyporesponsive to IFN‐γ. n scale cork roadbed dimensionsWebNov 20, 2024 · The interferon regulatory factors (IRFs) are a family of master transcription factors that regulate pathogen-induced innate and acquired immune responses. … n scale coffee table track plan

"WebNov 1, 2012 · Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. " - The irf family of transcription factors

The irf family of transcription factors

Interferon regulatory factor family of transcription …

WebThe interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into the type I interferon system. … WebA family of transcription factors, the interferon regulatory factors (IRF), was identified originally in the context of the regulation of the type I interferon (IFN)-alpha/beta system. The IRF family has now expanded to nine members, and gene-disruption studies have revealed the critical involvement …

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WebJul 6, 2016 · The influence of the IRF family transcription factors (TFs) on immune responses is mainly linked to the control of the type I interferon (IFN) system, which must … WebA hallmark of the innate immune response is the induction of the type I IFN (IFN-α/β) that occurs on activation of the signal-transducing pattern recognition receptors (PRRs) of the …

WebJan 18, 2024 · Interferon regulatory factors (IRFs) are an ancient family of transcription factors present in all main contemporary groups of metazoans from sponges to mammals, with common ancestors dating back to 600 million years ago [].All IRF members are structurally similar, with each possessing a highly conserved N-terminal DNA binding … WebApr 8, 2024 · The KLF family is composed of at least 18 transcription factors. They are widely distributed in eukaryotes and involved in embryonic development, tissue and organ maturation, stem cell generation ...

WebThe conversion of STAT proteins from latent to active transcription factors is central to cytokine signalling. Triggered by their signal-induced tyrosine phosphorylation, it is the assembly of a range of cytokine-specific STAT homo- and heterodimers that marks a key step in the transition of hitherto latent proteins to transcription activators. In contrast, the … WebSep 1, 2006 · The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs …

WebThe TALE gene family is an important transcription factor family that regulates meristem formation, organ morphogenesis, signal transduction, and fruit development. A total of 24 …

WebJan 5, 2010 · Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current … night shift work and risk of breast cancerWebNov 16, 2012 · Together, these studies demonstrate that a cooperative complex formed by a monomer of the interferon regulatory factor (IRF) family of transcription factors and a heterodimer of the activator protein–1 (AP-1) Jun and B cell activating transcription factor (BATF) has a major role in lineage specification and function in cells of the immune system. n scale distance between tracks n scale delivery trucksWebApr 14, 2011 · Interferon regulatory factors (IRFs) are a family of transcription factors comprised of nine members (IRF1-9) in mammalian cells. IRF10 has only been identified in avian species; its DNA homolog ... night shift work and weight gainWeb2 days ago · This internalization is crucial for activating IRF-3, which drives IFN-β synthesis, essential for the activation of STAT-1 and consequent synthesis of IRF-1, both crucial … n scale curved turnoutsWebInterferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). Interferon regulatory factors contain a conserved N … night shift work and type 2 diabetesWebMar 29, 2024 · This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and … n scale drive in theatre