Klotho genecard
WebAug 27, 2024 · Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family. The α-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and vitamin … WebDefinition of klotho in the Definitions.net dictionary. Meaning of klotho. What does klotho mean? Information and translations of klotho in the most comprehensive dictionary …
Klotho genecard
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WebApr 1, 2015 · The Klotho ( KL) gene encodes the α-Klotho protein. Information about the KL gene and its protein is provided in Table 1. The KL gene was identified by Kuro-o et al ( 1) in 1997 through a spontaneous mutation of the α-Klotho promoter region of α-Klotho. The mouse KL gene locus is located on chromosome 5 ( Figure 1) and flanked by PDS5B and … WebKlotho (A-9) is a mouse monoclonal antibody specific for an epitope mapping between amino acids 507-535 within an internal region of Klotho of human origin. PRODUCT Each …
WebGenes names: Klotho; Klotho Beta; Pathways: FGFR1c and Klotho ligand binding and activation WebFeb 6, 2024 · The klotho (kl) gene was identified as a regulator of normal ageing, where mutated forms led to accelerated ageing phenotypes. Therefore, klotho can be considered as an ‘ageing-suppressor’ gene.
WebMar 12, 2024 · α-Klotho is a geroprotective factor that exerts anti-physiological stress effects and protects against oxidative damage, hypoxia, and cytotoxic drugs., Soluble α-Klotho is an endocrine protein that regulates multiple biological processes, including phosphate homeostasis, mineral metabolism, and signaling by insulin-like growth factor 1 … WebNational Center for Biotechnology Information
WebNov 6, 1997 · A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that ...
WebMar 8, 2024 · Canagliflozin and sotagliflozin, however, increased Klotho protein concentration in the cell culture supernatant, an effect possibly due to up-regulation of ADAM17. Taken together, our investigations demonstrate complex effects of different SGLT2 inhibitors on αKlotho gene expression and protein secretion in renal MDCK and HK … cep de sao paulo jardim ikedaWebMay 11, 2024 · Klotho deficiency in Osx +-cells causes impaired bone remodeling. a, c Three-dimensional reconstruction from micro-computed tomography scans of the alveolar bone of OsxCre;KL fl/fl mice and their ... cep do grajauWebNov 9, 2024 · Klotho production in peripheral organs is highest in the kidney where it regulates vitamin D metabolism and the transport of phosphate and calcium (8, 11).Alternative splicing gives rise to two isoforms: secreted klotho (s-KL, amino acids 1 to 550 in mice) and full-length transmembrane klotho (m-KL, amino acids 1 to 1014 in mice) … cep do projeto n6WebAbstract. The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of ... cep do ma grajauWebNov 19, 2024 · The Klotho protein that was identified as the FGF23 co-receptor became known as αKlotho (encoded by the αKlotho gene; also known as KL ). βKlotho forms … cep do shopping jardins aracajuReduced α-klotho or FGF23 can result in impaired phosphate excretion from the kidney, leading to hyperphosphatemia. In mice, this leads to a phenotype characteristic of premature aging, which can be mitigated by feeding the mice a low phosphate diet. The plasma (soluble) form of α-klotho is most easily measured, and has been shown to decrease after 40 years of age in humans. Lower plasma levels of α-klotho in older adults is associated wi… cep dra odivaniaWebDec 8, 2024 · KLB klotho beta [ Homo sapiens (human) ] Gene ID: 152831, updated on 8-Dec-2024 Download Datasets Summary Official Symbol KLB provided by HGNC Official Full Name klotho beta provided by HGNC Primary source HGNC:HGNC:15527 AllianceGenome:HGNC:15527 Gene type RefSeq status Organism Lineage cep do projeto n3