Cryptophycin 中文
The crytophycins represent an extraordinarily potent class of cyanophyte-derived cytotoxins. As a consequence of their potent pharmacological activity, these compounds … WebA highly convergent synthesis of cryptophycins in their enantiomerically-pure forms was achieved. Our strategy consists of the synthesis of the two units 3 and 4 and linking them together to form the macrocyclic ring. The upper unit 3 was prepared from 10 in four steps, and the lower unit 4 was prepared from 20 in three steps. Enantioselective biocatalytic …
Cryptophycin 中文
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WebMay 11, 2000 · An efficient and highly stereoselective synthesis of cryptophycin B (2), a potent cytotoxic agent, is described. The ester-derived titanium-enolate-mediated syn-aldol reaction was employed to generate the stereocenters C(5) and C(6). The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycin B … WebCryptophycin is the cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity …
WebMar 15, 1996 · Cryptophycin is a(n) research topic. Over the lifetime, 150 publication(s) have been published within this topic receiving 3728 citation(s). The topic is also known as: cryptophycins. Popular works include Cryptophycin: A New Antimicrotubule Agent Active against Drug-resistant Cells, Total Synthesis of Cryptophycins. Revision of the Structures … WebCryptophycin is a potent antitumor agent that depletes microtubules in intact cells, including cells with the multidrug resistance phenotype. To determine the mechanism of action of cryptophycin, its effects on tubulin function in vitro were analyzed. Cryptophycin reduced the in vitro polymerization of bovine brain microtubules by 50% at a drug:tubulin ratio of 0.1.
WebThe cryptophycins are a unique family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. Their molecular target is tubulin protein … Webcas ir grid以发展机构知识能力和知识管理能力为目标,快速实现对本机构知识资产的收集、长期保存、合理传播利用,积极建设对知识内容进行捕获、转化、传播、利用和审计的能 …
WebThe specific aims of the proposed research are: 1) To select mutant strains for enhanced cryptophycin production; 2) To improve the process for cryptophycin production; and 3) …
WebMar 29, 2024 · 产品名称:Cryptophycin 1. cas:124689-65-2. 描述:Cryptophycin 1 是一种从 Nostoc sp. 中分离出来的有效的细胞毒性抗微管剂。. Cryptophycin 1 可以诱导细胞凋亡,并具有抗肿瘤活性和出色的抗增殖能力。. 分子量:655.18. sierra canyon baseball scheduleWebCryptophycin 52 has demonstrated a broad range of antitumor activity against both murine and human tumors. In the human MX-1 breast carcinoma xenograft cryptophycin 55 produced greater-than- additive tumor response in combination with 5-fluorouracil. In human non-small cell lung carcinoma and human small cell carcinoma xenografts ... the power chapter summaryWebJun 17, 2024 · Methods: A peptide-drug conjugate (ER-472) composed of Cltx linked to cryptophycin as warhead was developed as a tool to probe the molecular target and mechanism of action of Cltx, using multiple xenograft models. Results: Neuropilin-1 (NRP1), an endocytic receptor on tumor and endothelial cells, was identified as a novel Cltx target, … the power cherWebApr 8, 2005 · Abstract. Cryptophycin is a promising drug in many cancer therapies. Unfortunately, cryptophycin is expensive to produce synthetically because of its complex structure; however, certain strains of micro-algae naturally produce cryptophycin. This work studies the production of cryptophycin from two strains of Nostoc sp., ATCC 53789 and … the power checkinWebCryptophycin Affinity Labels: Synthesis and Biological Activity of a Benzophenone Analogue of Cryptophycin-24. クリプトフィシン親和性標識:クリプトフィシン-24のベンゾフェノン … the powerchair companyWebNov 26, 1998 · This enantiomerically pure Fragment A was conveniently and efficiently coupled with the other three fragments, namely B, C and D, and provided the desired cryptophycin A derivative (LY404291). The terminal double bond in LY404291 was further elaborated to provide a terminal epoxide LY404292 , and cryptophycins 51 and 52 . the power checkin textWebTraductions en contexte de "be epoxidation" en anglais-français avec Reverso Context : Oleic acid can be epoxidation to produce epoxy oleate (Plasticizer). sierra canyon bell schedule